
Comprehensive Support
Understand the neurodiversity movement, history of autism in clinical care and ethical approaches to patient education when offering treatment to Autistic adults or children.

Evidence-Based Learning
Implement safe dosing strategies based on available research for optimal patient outcomes.

Personalized Application
Apply decision-making frameworks to personalize folinic acid therapy for individual patient needs.
About the Course
This course is tailored for licensed medical professionals including psychiatric nurse practitioners, family nurse practitioners and pediatric nurse practitioners specializing in treating individuals with autism spectrum disorder (ASD) and related conditions. Dive deep into the use of folinic acid, understand the differentiation between prescription and OTC options, and learn safe dosing strategies and monitoring protocols. By the end, confidently integrate leucovorin (folinic acid) into ASD care plans.

Meet Your Instructor
My name is Maria Ingalla, and I am a psychiatric mental health nurse practitioner who has spent the last decade . I currently own a prominent neuroaffirming psychiatry practice in Arizona, and offer free mental health education for the public on social media. I am an autistic mom to two autistic children who are both prescribed leucovorin. I offer a unique perspective to fully understand integrating leucovorin into clinical practice.
Curriculum
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1
Welcome to the Course!
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How to use this course
- This is a course brought to you by Paperflower Institute Free preview
- Folinic Acid in Autism: Prescription & OTC Approaches Free preview
- Meet Your Course Instructor Free preview
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2
MODULE 1: Autism 101
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Video Lecture: Module 1: Autism 101
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Understanding Autism
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The History of Autism
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The Impact
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Variations in Presentation
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The Autistic Experience
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Parenting Struggles
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3
MODULE 2: Folinic Acid Fundamentals
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Video Lecture: Module 2: Folinic Acid Fundamentals
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Core Concepts You Should Know
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The Role of Folate
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The Folate Cycle
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Folinic Acid + B12: Why They Belong Together
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Folate and Autism
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FRAA and FRAT
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MTHFR?
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Clinical Consequences of Elevated Homocysteine
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When the Cycle is Compromised
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Let’s Build a House
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The Downside of Folic Acid
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What about the other parts?
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How does this relate to MTHFR or FRAT?
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What does this even mean?
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Case-Based Clinical Scenarios
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4
MODULE 3: The Evidence
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Video Lecture: Module 3: The Evidence
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Is the Evidence Enough?
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Some of the Studies pt. 1
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Some of the Studies pt. 2
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Some of the Studies pt. 3
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The Case Reports
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5
MODULE 4: Utilizing Folinic Acid
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Video Lecture: Module 4: Utilizing Folinic Acid
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Over-the-Counter Use
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OTC Folinic Acid: Is Low-Dose Worth It?
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RX: Leucovorin pt. 1 (Formulations and Alternatives)
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RX: Leucovorin pt. 2 (Oral Bioavailability of Leucovorin)
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RX: Leucovorin pt. 3 (Pharmacokinetics of Oral Folinic Acid)
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RX: Leucovorin pt. 4 (Pharmacokinetics of Folinic Acid)
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Optimization (B12 and Cofactor Support)
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Administration Strategies
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Pregnancy & Breastfeeding
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6
MODULE 5: Safety, Monitoring, & Lab Work
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Video Lecture: Module 5: Safety, Monitoring, & Lab Work
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Safety, Monitoring, & Lab Work
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Most common side effects
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Less Common Side Effects and Adverse Reactions
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Long-Term Effects
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Mechanistic Theories Linking Folate, B12, and Cancer
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Relevant Interactions
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7
MODULE 6: Communication, Expectations and Informed Consent
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Video Lecture: Module 6: Communication, Expectations, and Informed Consent
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Setting the Expectation
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Ethical Considerations
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Engaging Patients and Caregivers
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Building a Collaborative Care Plan
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Case Report: A Beneficial Case
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Video Lecture: Case Report: A Beneficial Case
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8
Handouts
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What is the Methyl Trap?
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Why Folinic Acid Needs B12
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OTC vs Rx Folinic Acid
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Quick-Start Algorithm
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Adult FAQ: Leucovorin (Folinic Acid) for ADHD & Autism
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Leucovorin (Prescription Folinic Acid) and OTC Folinic Acid Q&A Guide
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Folinic Acid Key Trial Summaries
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Folinic Acid: What Families Should Know
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Folinic Acid vs. L-Methylfolate vs. Folic Acid Quick Compare Card
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Vitamin B12 & B6 Pairing Guide
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Prescriber Cheat Sheet: Folinic Acid Use in ADHD & ASD
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Parent Folinic Acid Response Log
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House Analogy: "Let’s Build a House"
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PPT: Prescription Essentials: Leucovorin
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9
Course Quiz and References
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Video Lecture: References
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References
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Course Quiz (5 Items)
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Ready to Learn?
Enroll now to develop a comprehensive understanding of folate, folinic acid/leucovorin and the role in the brain for neurodivergent individuals. Pending ANCC approval for CEUs.
$30.00